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KMID : 0385019930090010057
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Korean Journal of Laboratory Animal Science
1993 Volume.9 No. 1 p.57 ~ p.64
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Relationship between Fetal Weight and Ossification of Ktc:ICR Mice and Ktc:SD Rats
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노정구/Roh, Jung Koo
김정란/정문구/한상섭/Kim, Jeong Ran/Chung, Moon Koo/Han, Sang Seop
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Abstract
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In the SPF ICR mice and Sprague-Dawley(SD) rats, the relationship between fetal weight and number of ossification centers of some skeletal districts on day 1$ or 20 post conceptionem(p.c.) was analyzed. The average rate of ossification was also calculated. The following results were obtained:
ICR mice-data
1. The ossification of sternebrae, metacarpi, metatarsi and vertebrae cervicales was nearly complete and largely independent of fetal weight.
2. The ossification of phalanges and paws of foot is complete in fetuses weighing more than 1.5g. In fetuses with a lower weight there was a linear relationship between these two parameters.
3. The ossification of phalanges and paws of hand is incomplete and largely independent of fetal weight.
4. The ossification of vertebrae sacrocaudales was incomplete end varied depending on the fetal weight.
SD rats-data
1. The ossification of sternebrae, metacarpi and vertebrae sacrocaudales was incomplete and varied depending on the fetal weight.
2. The ossification of metatarsi was nearly complete.
From all the association investigated the number of vertebrae sacrocaudales showed the strongest correlation with fetal weight in both mice and rats. The rate of ossification of vertebrae sacrocaudales was found to be a useful variable when studying drug-induced retardation effect.
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